3-Nitroa niline
3-Nitroaniline
CAS: 99-09-2
Molecular Formula: C6H6N2O2
3-Nitroa niline - Names and Identifiers
| Name | 3-Nitroaniline |
| Synonyms | C.I. 37030 3-NitroaniL M-NITRANILINE Fast Orange R m-Nitroaniline 3-Nitroaniline N-nitroaniline M-NITROANILINE m-nitro-anilin 3-Nitroa niline fastorangersalt m-Nitro aniline fast orange R base m-Nitroaminobenzene hiltonilfastorangerbase Solvent Yellow 14 (12055) Hiltonil Fast Orange R Base C.I. Azoic Diazo Component 7 |
| CAS | 99-09-2 |
| EINECS | 202-729-1 |
| InChI | InChI=1/C6H6N2O2/c9-8(10)7-6-4-2-1-3-5-6/h1-5,7H |
3-Nitroa niline - Physico-chemical Properties
| Molecular Formula | C6H6N2O2 |
| Molar Mass | 138.12 |
| Density | 0,901 g/cm3 |
| Melting Point | 111-114 °C (lit.) |
| Boling Point | 306 °C |
| Flash Point | 196 °C |
| Water Solubility | 1.25 g/L |
| Solubility | 1.25g/l |
| Vapor Presure | 1 mm Hg ( 119 °C) |
| Appearance | Crystals, Crystalline Powder and/or Chunks |
| Specific Gravity | 0.901 |
| Color | Yellow to ochre-yellow to orange |
| Merck | 14,6581 |
| BRN | 636962 |
| pKa | 2.466(at 25℃) |
| Storage Condition | Store below +30°C. |
| Refractive Index | 1.6396 (estimate) |
| Physical and Chemical Properties | Yellow needle-like crystal or powder. melting point 114 ℃ boiling point 286~307 ℃ (decomposition) relative density 1.1747 solubility slightly soluble in water, soluble in ethanol, ether, methanol. |
| Use | Slightly soluble in water, soluble in ethanol, ether, methanol. |
3-Nitroa niline - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R33 - Danger of cumulative effects R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S28A - |
| UN IDs | UN 1661 6.1/PG 2 |
| WGK Germany | 2 |
| RTECS | BY6825000 |
| FLUKA BRAND F CODES | 8 |
| TSCA | Yes |
| HS Code | 29214210 |
| Hazard Class | 6.1 |
| Packing Group | II |
| Toxicity | Acute LD50 for guinea pigs 450 mg/kg, mice 308 mg/kg, quail 562 mg/kg, rats 535 mg/kg (quoted, RTECS, 1985). |
3-Nitroa niline - Nature
Open Data Verified Data
yellow needle-like crystals or powder. Melting point 114 °c. Boiling point of 286~307 degrees C (decomposition). The relative density was 1.1747. Slightly soluble in water, soluble in ethanol, ether, methanol. With inorganic acids to form water-soluble salts.
Last Update：2024-01-02 23:10:35
3-Nitroa niline - Preparation Method
Open Data Verified Data
with nitrobenzene as raw material, nitric acid and sulfuric acid were mixed into mixed acid for nitrification to produce m-dinitrobenzene, which was refined by sulfurous acid to obtain m-dinitrobenzene product. Sodium polysulfide was prepared from sulfur and sodium sulfide. M-dinitrobenzene was reduced to M-nitroaniline with sodium polysulfide, and the reaction product was recrystallized and filtered to obtain a finished product.
Last Update：2022-01-01 10:51:40
3-Nitroa niline - Use
Open Data Verified Data
mainly used as intermediates in organic synthesis and dye intermediates, can be used as ice dye orange base R and preparation of phenol AS-BS.
Last Update：2022-01-01 10:51:39
3-Nitroa niline - Safety
Open Data Verified Data
- can cause more intense blood poisoning than aniline and cause cyanosis. Rat oral LD50 900mg/kg. When the skin is contaminated with M-nitroaniline, if it is scrubbed with a solvent such as ethanol, the absorption area and absorption rate will be increased, and the danger will occur. Therefore, it should be scrubbed with polyethylene glycol. Due to its strong blood toxicity, special attention should be paid when handling powders. The maximum allowable concentration in workplace air is 1 × 10-6. Production equipment should be sealed to prevent run, run, drop, leakage. Wear protective equipment during operation. After contact, a large amount of water was used to rinse for 15 minutes. The patient should wash and wear the clothes after they are contaminated.
- packed with an iron drum lined with plastic bags, 50kg per barrel, the barrel should be labeled with "drug. The container should be sealed, should be placed in a cool, dry, ventilated place, not exposed to the sun, not mixed with organic matter, flammable materials or food, should be far away from the fire source, heat source. Handle with gentle handling. The drug was stored and transported in accordance with the regulations for the administration of highly toxic drugs.
Last Update：2022-01-01 10:51:40
3-Nitroa niline - Reference Information
| Color index | 37030 |
| Henry's Law Constant | 1.93 x 10-5 atm?m3/mol at 25 °C (approximate - calculated from water solubility and vapor pressure) |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| purpose | used as pharmaceutical and dye intermediate used in organic synthesis and pine wood color inspection, also used as dye intermediate mainly used as organic synthesis intermediate and dye intermediate. Can be used as ice dye orange base R and preparation of phenol AS-BS. 3-nitro-n, N-diethanol aniline can be obtained by hydroxyethylating M-nitroaniline with ethylene oxide. slightly soluble in water, soluble in ethanol, ether, methanol. used as dye intermediate and in organic synthesis, also used for Pine color test, acid-base indicator, ph 8.6 (colorless)-(yellow). |
| production method | with nitrobenzene as raw material, nitric acid and sulfuric acid were mixed into mixed acid for nitration to produce m-dinitrobenzene, which was refined by sulfurous acid, the M-dinitrobenzene product was obtained. Sodium polysulfide was prepared by using sulfur and sodium sulfide as raw materials, and M-dinitrobenzene was reduced to M-nitroaniline by using sodium polysulfide. The reaction product was recrystallized and filtered to obtain a finished product. Raw material consumption quota: nitrobenzene 1319kg/t, nitric acid 845kg/t, sulfuric acid 2050kg/t, sodium sulfide 707kg/t, sulfur 271kg/t. |
| category | toxic substances |
| toxicity grade | high toxicity |
| Acute toxicity | oral-rat LD50: 535 mg/kg; Oral-mouse LD50: 308 mg/kg |
| flammability hazard characteristics | flammable in case of open flame; Toxic nitrogen oxide fumes from combustion; reaction with oxidant |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature, separate storage of food additives |
| fire extinguishing agent | carbon dioxide, foam, sand, water mist |
| spontaneous combustion temperature | 521 ℃ |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
Supplier List
Product Name: Apixaban Impurity 181 Request for quotation
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: 3-Nitroaniline Request for quotation
CAS: 99-09-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 99-09-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Product Name: 3-nitroaniline m-nitroaniline Request for quotation
CAS: 99-09-2
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987
Wechat: 13605431940
WhatsApp: 13605431940
CAS: 99-09-2
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987
Wechat: 13605431940
WhatsApp: 13605431940
Product Name: Apixaban Impurity 181 Request for quotation
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: 3-Nitroaniline Request for quotation
CAS: 99-09-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 99-09-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Product Name: 3-nitroaniline m-nitroaniline Request for quotation
CAS: 99-09-2
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987
Wechat: 13605431940
WhatsApp: 13605431940
CAS: 99-09-2
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987
Wechat: 13605431940
WhatsApp: 13605431940
View History